An Experimental Study on the Healing Effect of Water to Traditional Sudanese Liquor (Aragi)-induced Stomach Peptic Ulcers

Entisar Kuku Yousif, Howeida Abdullah Mustafa, Alkhair Abd Almahmoud Idris

Abstract


Background: Peptic ulcer is one of the most common gastrointestinal tract diseases which affect the stomach. This study aimed to determine the effect of aragi on the adult rats' stomach and investigate the effect of water as a therapeutic agent on aragi-induced ulcerations.

Materials and methods: Thirty-five adult Wistar albino rats were used in this experimental study. Five rats were sacrificed on day 0, 5 rats were used as a control group, and 25 rats were treated with aragi. On day 15, all rats in the control group and five aragi-treated rats were sacrificed for histological examination of the stomachs. The remaining 20 rats were stopped from aragi intake and 10 of them were treated with water for 15 days. After 15 day, all rats were sacrificed for histopathological examination of their stomachs. Stomach tissues were stained using hematoxylin and eosin (H&E) and documented under a microscope.

Results: Our research showed that aragi-treated rats had different severity of peptic ulcers after 15 days of continuous aragi intake, while the control group showed normal stomach histology. Nine out of 10 rats treated by water after aragi treatment also showed normal stomach histology.

Conclusion: Aragi is a causative agent for peptic ulcer and water can be used as potential natural therapy for treating ulcerative stomach.

Keywords: aragi, water, stomach, peptic ulcer


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References


Goldman L, Ausiello D. Cecil Textbook of Medicine. 22nd ed. Philadelphia: Saunders; 2004, article.

Glavas MM, Weinberg J. Stress, alcohol consumption, and the hypothalamic-pituitary-adrenal axis. In: Yehuda S, Mostofsky DI, editors. Nutrients, Stress, and Medical Disorders. Totowa: Humana Press; 2006. p.165-83, article.

Ahmed AS. Abdalbagi NH, Mustafa HA, Idris AA, Ismail AMA, Abd Alla RE. The role of camel milk in the reactivation of liver damaged by Sudanese liquor (aragi). Sudan J Public Health. 2011; 6(4):157-63, article.

Cassens BJ. Preventive Medicine and Public Health. 2nd ed. Malvern: Harwal Publishing; 1992, article.

Hassan TH, Mustafa HA, Idris AA, Ismail AMA, AbdAlla RE. An experimental study on the impact of traditional Sudanese liquor (aragi) in the aetiology of liver damage. Sudan J Public Health. 2008; 3(3): 125-30, article.

Elgamal AA, A/karim EI, Ibrahim KE. Analysis of the alcoholic drink (aragi). J Crim Soc Sci. 2003; 6: 340-52.

Rezvani AH, Overstreet DH, Perfumi M, Massi M. Plant derivatives in the treatment of alcohol dependency. Pharmacol Biochem Behav. 2003; 75(3): 593-606, CrossRef.

Fleming SA, Gutknecht NC. Naturopathy and the primary care practice. Prim Care. 2010; 37(1): 119–36, CrossRef.

Malanga G, Yan N, Stark J. Mechanisms and efficacy of heat and cold therapies for musculoskeletal injury. Postgrad Med. 2014; 127(1): 57–65, CrossRef.

Garra G, Singer AJ, Leno R, Taira BR, Gupta N, Mathaikuty B, et al. Heat or cold packs for neck and back stain: A randomized controlled trial of efficacy. Acad. Emerg. Med. 2010; 17(5): 484–9, CrossRef.

Committee for the Purpose of Control and Supervision on Experiments on Animals. CPCSEA guidelines for laboratory animal facility. Indian J Pharmacol. 2003; 35: 257-74, article.

Bancroft JD, Gamble M. Theory and Practice of Histological Techniques. 5th ed. London: Churchill Livingstone; 2002, article.

Yim MH, Kim KH, Lee BJ. The number of household members as a risk factor for peptic ulcer disease. Sci Rep. 2021; 11(1): 5274, CrossRef.

Bayyurt N, Abasiyanik MF, Sander E, Salih BA. Canonical correlation analysis of factors involved in the occurrence of peptic ulcers. Dig Dis Sci. 2007; 52(1): 140–6, CrossRef.

Al Moutaery M, Al Rayes H, Al Swailam R, Elfaki I, Khan HA, Arshaduddin M, et al. Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats. Exp Toxicol Pathol. 2012; 64(3):233-7, CrossRef.

Tariq M, Khan HA, Elfaki I, Arshaduddin M, Al Moutaery M, Al Rayes H, et al. Gastric antisecretory and antiulcer effects of simvastatin in rats. J Gastroenterol Hepatol. 2007; 22(12): 2316-23, CrossRef.

Becker BE. Aquatic therapy: Scientific foundations and clinical rehabilitation applications. PM&R. 2009; 1(9): 859-72, CrossRef.

Kjellgren A, Sundequist U, Norlander T, Archer T. Effects of flotation-REST on muscle tension pain. Pain Res Manag. 2001; 6(4): 181-9, CrossRef.




DOI: https://doi.org/10.21705/mcbs.v6i2.233

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