The Effects of Moringa oleifera Leaves on Complete Blood Count, Renal and Liver Functions as Potential Therapy for Malnutrition

Gamar Musa Kodi, Howeida Abdullah Mustafa, Alkhair Abd Almahmoud Idris


Background: Moringa oleifera which is available in many areas all over the world including Sudan is low-cost and traditionally used in the treatment of many disorders, including malnutrition. This study aimed to determine the effect of aqueous extract of M. oleifera leaves in renal, liver functions and complete blood count (CBC) parameters, and its potential as therapy for malnutrition.

Materials and methods: This was an experimental case control study using twenty-five Wistar albino rats. Rats were divided into three groups: normal protein diet group, low protein diet with or without M. oleifera extract groups. We determined rats' weight, CBC parameters, blood mineral concentrations, as well as liver and renal functions at day 0, 7, and 14.

Results: Our findings showed that rats' weight were significantly different between the three groups at day 0, 7, and 14. Rats' weight, blood sodium, potassium, calcium, and urea concentration, as well as Hb concentration, TWBCs count, total platelets count, and %lymphocyte showed significant differences between three groups at day 0, 7, and 14.

Conclusion: M. oleifera leaves can be used as potential therapy for malnutrition because they have some effects on weight, blood mineral concentrations, renal and liver function, as well as CBC parameters.

Keywords: ALP, AST, ALT, creatinine, Moringa oleifera

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World Health Organization. Safer Water, Better Health. Geneva: World Health Organization; 2019, article.

The United Nations International Children's Emergency Fund. The State of the World’s Children 1998: Focus on Nutrition. New York: Oxford University Press; 1998, article.

Potani I, Spiegel-Feld C, Brixi G, Bendabenda J, Siegfried N, Bandsma RHJ, et al. Ready-to-use therapeutic food (RUTF) containing low or no dairy compared to standard RUTF for children with severe acute malnutrition: A systematic review and meta-analysis. Adv Nutr. 2021; 12(5): 1930-43, CrossRef.

Choudhury N, Ahmed T, Hossain MI, Islam MM, Sarker SA, Zeilani M, et al. Ready-to-use therapeutic food made from locally available food ingredients is well accepted by children having severe acute malnutrition in Bangladesh. Food Nutr Bull. 2018; 39(1): 116-26, CrossRef.

World Health Organization. Management of Severe Malnutrition: A Manual for Physicians and Other Senior Health Workers. Geneva: World Health Organization; 1999, article.

Hassan TH, Mustafa HA, Idris AA, Ismail AMA, AbdAlla RE. An experimental study on the impact of traditional Sudanese liquor (aragi) in the aetiology of liver damage. Sudan J Public Health. 2008; 3(3): 125-30, article.

Ahmed AS, Abdalbagi NH, Mustafa HA, Idris AA, Ismail AMA, Abd Alla RE. The role of camel milk in the reactivation of liver damaged by Sudanese liquor (aragi). Sudan J Public Health. 2011; 6(4): 157-63, article.

Khanna P, Jain SC, Panagariya A, Dixit VP. Hypoglycemic activity of polypeptide-p from a plant source. J Nat Prod. 1981; 44(6): 648-55, CrossRef.

Cheesbrough M. Medical Laboratory Manual for Tropical Countries. Volume I. Boston: Butterworths; 1987, article.

Martin G. The principles of automated blood cell counters. In: Burnett D, Crocker J, editors. The Science of Laboratory Diagnosis. 2nd ed. West Sussex: Wiley; 2005. p.290-95, article.

Buttarello M, Bulian P, Temporin V, Rizzotti P. Sysmex SE-9000 hematology analyzer: Performance evaluation on leukocyte differential counts using an NCCLS H20-A protocol. National Committee for Clinical Laboratory Standards. Am J Clin Pathol. 1997; 108(6): 674–86, CrossRef.

Mendenhall W. Introduction to Probability and Statistics. 3rd ed. Belmont: Wadsworth Publishing Company Inc.; 1971.

Statistical Analysis System. SAS User’s Guide. Cary: SAS Institute Inc.; 1996.

Kumssa DB, Joy EJ, Young SD, Odee DW, Ander EL, Broadley MR. Variation in the mineral element concentration of Moringa oleifera Lam. and M. stenopetala (Bak. f.) Cuf.: Role in human nutrition. PLoS One. 2017; 12(4): e0175503, CrossRef.

Su B, Chen X. Current status and potential of Moringa oleifera leaf as an alternative protein source for animal feeds. Front Vet Sci. 2020; 7: 53, CrossRef.

Goodhart RS, Shills ME. Modern Nutrition in Health and Disease. 11th ed. New York: Academic Press; 2021.

Pankaja N, Prakash J. Availability of calcium from kilkeerai (Amaranthus tricolor) and drumstick (Moringa oleifera) greens in weaning rats. Nahrung. 1994; 38(2): 199-203, CrossRef.

Djakalia B, Guichard BL, Soumalia D. Effect of Moringa oleifera on growth performance and health status of of young post-weaning rabbits. Res J Poult Sci. 2011; 4(1): 7-13, CrossRef.

Idohou-Dossou N, Diouf A, Gueye AL, Guiro AT, Wade S. Impact of daily consumption of Moringa (Moringa oleifera) dry leaf powder on iron status of Senegalese lactating women. African J Food Agric Nutr Dev. 2011; 11(4): 4989–99, CrossRef.

Hadis M, Gebreyohannes Y, Gemeda N. Potential therapeutic uses of Moringa stenopetala: a scoping review. J Glob Health Sci. 2020; 2(2): e26, CrossRef.

Bayu F, Afework M, Geleta B, Ergete W, Makonnen E. Effect of chronic administration of aqueous leaves extract of Moringa stenopetala on blood parameters and histology of liver and kidney in rats. Ethiop J Health Sci. 2020; 30(2): 259-68, CrossRef.

Popoola JO, Obembe OO. Local knowledge, use pattern and geographical distribution of Moringa oleifera Lam. (Moringaceae) in Nigeria. J. Ethnopharmacol. 2013; 150(2): 682–91, CrossRef.

Sivasankari B, Anandharaj M, Gunasekaran P. An ethnobotanical study of indigenous knowledge on medicinal plants used by the village peoples of Thoppampatti, Dindigul district, Tamilnadu, India. J. Ethnopharmacol. 2014; 153(2): 408–23, CrossRef.


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