Association between 25(OH)D3 Levels and the Presence of COVID-19 Symptoms
Abstract
Background: Recently, there have been studies reporting a relationship between vitamin D levels in the blood and the immune system. This study aimed to analyze the association between vitamin D levels and symptoms of coronavirus disease 2019 (COVID-19).
Materials and methods: This study was an analytical survey study with a cross-sectional approach, with lecturers at Universitas Malahayati that have been infected with COVID-19 in 2022 as subjects. Total 47 subjects were included. Subjects were fasted overnight, then blood samples were taken from subjects in the next morning. The blood was centrifuged, then the serum was separated for examination by the direct competitive chemiluminescence immunoassay (CLIA) method using Architect 25-OH Vitamin D Reagent. Data was analyzed using logistic regression.
Results: None of the subjects had normal blood levels of 25(OH)D3 and almost half (48.9%) of the subjects had symptoms when infected with COVID-19. There was a significant relationship between the level of 25(OH)D3 (p=0.001) and the status of the COVID-19 vaccine (p=0.013) with the presence of symptoms in COVID-19 patients.
Conclusion: The lower the level of 25(OH)D3 in the blood and the more incomplete the COVID-19 vaccine, the greater the onset potential of COVID-19 symptoms. It is necessary to maintain vitamin D intake and increase the coverage of the COVID-19 vaccine, especially at booster doses.
Keywords: vitamin D, COVID-19, vaccination, health protocol
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Yuliawuri H, Christian JE, Steven N. Non-synonymous mutation analysis of SARS-CoV-2 ORF3a in Indonesia. Mol Cell Biomed Sci. 2022; 6(1): 20-7, CrossRef.
Satuan Tugas Penanganan COVID-19 [Internet]. Jakarta: Satuan Tugas Penanganan COVID-19; ©2021. Peta Sebaran [update 2022 Jun 1; cited 2022 Jun 1]. Available from: https://covid19.go.id/.
Satuan Tugas Penanganan COVID-19 [Internet]. Jakarta: Satuan Tugas Penanganan COVID-19; ©2021. Capaian Vaksinasi COVID-19 di Luar Jawa Bali Masih Rendah [update 2022 Jul 2; cited 2022 Jul 30]. Available from: https://covid19.go.id/.
Farmawati C, Ula M, Qomariyah Q. Prevention of COVID-19 by strengthening body’s immune system through self-healing. Populasi J Kependud Kebijak. 2021; 28(2): 70-81, CrossRef.
Hermawan D. Sehat Selalu dengan Vitamin D. Yogyakarta: Penerbit Andi; 2016.
Hermawan D. Manfaat Vitamin D pada Era Pandemi Covid-19. Yogyakarta: Penerbit Andi; 2021.
Trivedi GY, Saboo B. The risk factors for immune system impairment and the need for lifestyle changes. J Soc Health Diabetes. 2020; 8(1): 25–8, CrossRef.
Hermawan D, Widodo S. Kadar 25(OH)D3 darah pada penderita obesitas. J Gizi Klin Indones. 2021; 18(1): 1-7, CrossRef.
Hermawan D, Muhani N, Arisandi S. Blood vitamin D levels in hypercholesterolemic patients. J Aisyah J Ilmu Kesehat. 2022; 7(1): 101–6, CrossRef.
Manousaki D, Richards JB. Low vitamin D levels as a risk factor for cancer. BMJ. 2017; 359: j4952, CrossRef.
Sigmund CD. Regulation of renin expression and blood pressure by vitamin D(3). J Clin Invest. 2002; 110(2): 155-6, CrossRef.
Maruotti N, Cantatore FP. Vitamin D and the immune system. J Rheumatol. 2010; 37(3): 491-5, CrossRef.
Pinzon R, Wijaya VO, Paramitha D. Vitamin D status and cognitive performance of post stroke patients. Mol Cell Biomed Sci. 2021; 5(1): 22-6, CrossRef.
Youssef S. Modulating effect of vitamin D on iNOS, PCNA and α-SMA expression against diclofenac sodium induced gastric injury in rats. Indones Biomed J. 2020; 12(2): 165–76, CrossRef.
Vanlint S. Vitamin D and obesity. Nutrients. 2013; 5(3): 949-56, CrossRef.
Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017; 18(2): 153-65, CrossRef.
Holick MF. The vitamin D deficiency pandemic: A forgotten hormone important for health. Public Health Rev. 2010; 32: 267–83, CrossRef.
Alfredsson L, Armstrong BK, Butterfield DA, Chowdhury R, de Gruijl FR, Feelisch M, et al. Insufficient sun exposure has become a real public health problem. Int J Environ Res Public Health. 2020; 17(14): 5014, CrossRef.
Mendes MM, Hart KH, Botelho PB, Lanham-New SA. Vitamin D status in the tropics: Is sunlight exposure the main determinant? Nutr Bull. 2018; 43(4): 428–34, CrossRef.
Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020; 13(10): 1373-80, CrossRef.
Asyary A, Veruswati M. Sunlight exposure increased Covid-19 recovery rates: A study in the central pandemic area of Indonesia. Sci Total Environ. 2020; 729: 139016, CrossRef.
Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013; 5(7): 2502-21, CrossRef.
Bui L, Zhu Z, Hawkins S, Cortez-Resendiz A, Bellon A. Vitamin D regulation of the immune system and its implications for COVID-19: A mini review. SAGE Open Med. 2021; 9: 20503121211014073, CrossRef.
Panfili FM, Roversi M, D'Argenio P, Rossi P, Cappa M, Fintini D. Possible role of vitamin D in Covid-19 infection in pediatric population. J Endocrinol Invest. 2021; 44(1): 27-35, CrossRef.
Saluy PM, Langingi NL, Kaparang GF. Sunbathing as caring for Covid-19 patients: A literature review. Aksara J Ilmu Pendidik Nonform. 2022; 8(3): 2397–408, CrossRef.
Sharun K, Tiwari R, Dhama K. COVID-19 and sunlight: Impact on SARS-CoV-2 transmissibility, morbidity, and mortality. Ann Med Surg. 2021; 66: 102419, CrossRef.
Tushabe F. Comparison of COVID-19 severity between tropical and non-tropical countries. Int J Infect. 2020; 7(3): e104142, CrossRef.
Wise J. Covid-19: Symptomatic infection with omicron variant is milder and shorter than with delta, study reports. BMJ. 2022; 377: o922, CrossRef.
Abate BB, Kassie AM, Kassaw MW, Aragie TG, Masresha SA. Sex difference in coronavirus disease (COVID-19): A systematic review and meta-analysis. BMJ Open. 2020; 10(10): e040129, CrossRef.
Ciarambino T, Para O, Giordano M. Immune system and COVID-19 by sex differences and age. Womens Health. 2021; 17: 17455065211022262, CrossRef.
Perrotta F, Corbi G, Mazzeo G, Boccia M, Aronne L, D'Agnano V, et al. COVID-19 and the elderly: Insights into pathogenesis and clinical decision-making. Aging Clin Exp Res. 2020; 32(8): 1599-608, CrossRef.
Nimitphong H, Holick MF. Vitamin D status and sun exposure in southeast Asia. Dermatoendocrinol. 2013; 5(1): 34-7, CrossRef.
Hermawan D, Andoko A. Hubungan antara kadar vitamin D dalam darah dengan tekanan darah usia lanjut di Natar Lampung Selatan. J. Keperawatan Sriwij. 2019; 6(1): 1–8, article.
Abeya SG, Barkesa SB, Sadi CG, Gemeda DD, Muleta FY, Tolera AF, et al. Adherence to COVID-19 preventive measures and associated factors in Oromia regional state of Ethiopia. PLoS One. 2021; 16(10): e0257373, CrossRef.
Killeit U. Vitamin D status and COVID-19. Dtsch Leb. 2022; 118: 1–6.
Chirumbolo S, Bjørklund G, Sboarina A, Vella A. The role of vitamin D in the immune system as a pro-survival molecule. Clin Ther. 2017; 39(5): 894-916, CrossRef.
Doerre A, Doblhammer G. The influence of gender on COVID-19 infections and mortality in Germany: Insights from age- and gender-specific modeling of contact rates, infections, and deaths in the early phase of the pandemic. PLoS One. 2022; 17(5): e0268119, CrossRef.
Statsenko Y, Al Zahmi F, Habuza T, Almansoori TM, Smetanina D, Simiyu GL, et al. Impact of age and sex on COVID-19 severity assessed from radiologic and clinical findings. Front Cell Infect Microbiol. 2022; 11: 777070, CrossRef.
Freund O, Tau L, Weiss TE, Zornitzki L, Frydman S, Jacob G, et al. Associations of vaccine status with characteristics and outcomes of hospitalized severe COVID-19 patients in the booster era. PLoS One. 2022; 17(5): e0268050, CrossRef.
Ng OT, Marimuthu K, Lim N, Lim ZQ, Thevasagayam NM, Koh V, et al. Analysis of COVID-19 incidence and severity among adults vaccinated with 2-dose mRNA COVID-19 or inactivated SARS-CoV-2 vaccines with and without boosters in Singapore. JAMA Netw Open. 2022; 5(8): e2228900, CrossRef.
DOI: https://doi.org/10.21705/mcbs.v7i1.306
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